Coronavirus around the world

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  • Not sure it’s because of the We Hate Putin lobby. The FDA is notoriously slow, even when the drug being considered is made in the USA.


    From Healthline.com:


    Why is the Sputnik V COVID-19 vaccine not yet approved in the US?

    In the United States, all vaccines must go through a rigorous development process before being approved for use by the Food and Drug Administration (FDA).

    According to the FDATrusted Source, vaccine development begins with the exploration and testing of potential compounds that can be used to prevent or treat a certain disease. This initial research and testing phase can include testing on cells or animals, and afterward, clinical development begins.

    At the clinical development stage, a vaccine must go through three phases of testing before it can be reviewed for approval:

    • Phase I. During phase I, the vaccine is tested on small groups of people.
    • Phase II. During phase II, the vaccine is tested on larger groups of people who are the intended recipients of the vaccine.
    • Phase III. During phase III, the vaccine is administered to thousands of people and clinical testing is performed for safety and effectiveness.

    After Phase III trials prove a vaccine is both safe and effective, it then enters the approval process. The vaccine approval process includes:

    • applications
    • inspections
    • additional testing

    Only after a new vaccine has completed every step of the development and approval process can it enter the market for distribution in the United States.

    As you can see, this lengthy process means that it can take years for a vaccine to receive approval for distribution in the United States — especially if the vaccine is from another country, which is the case for Sputnik V.”

  • But approval for distribution is far different from recognition that a person who has received the vaccine is legitimately vaccinated. Can either of you cite a source that could help us understand?

    From my understanding until the WHO/EU approves it then most countries won't accept you as being vaccinated despite the fact you are. Of course that only really affects those who wish to travel.

  • From The Times today:

    Michelle Bolsonaro, the first lady of Brazil, defied her husband's stance as she received an inoculation in America. President Bolsonaro, 66, who has been outspoken in refusing the jab, ignored health regulations and gave the opening speech at the UN general assembly in New York.


    Why in the world is this nut job giving the opening speech at the UN General Assembly?

  • This NYT report gives us some understanding of an emerging two-month pattern, and some reason to hope we’ve seen not the end, but perhaps the worst of Covid-19.  


    Worldwide, cases have also dropped more than 30 percent since late August. “This is as good as the world has looked in many months,” Dr. Eric Topol of Scripps Research wrote last week.

    These declines are consistent with a pattern that regular readers of this newsletter will recognize: Covid’s mysterious two-month cycle. Since the Covid virus began spreading in late 2019, cases have often surged for about two months — sometimes because of a variant, like Delta — and then declined for about two months.

    Epidemiologists do not understand why. Many popular explanations, like seasonality or the ebbs and flows of social distancing, are clearly insufficient, if not wrong. The two-month cycle has occurred during different seasons of the year and occurred even when human behavior was not changing in obvious ways.

    The most plausible explanations involve some combination of virus biology and social networks. Perhaps each virus variant is especially likely to infect some people but not others — and once many of the most vulnerable have been exposed, the virus recedes. And perhaps a variant needs about two months to circulate through an average-sized community.

    Human behavior does play a role, with people often becoming more careful once caseloads begin to rise. But social distancing is not as important as public discussion of the virus often imagines. “We’ve ascribed far too much human authority over the virus,” as Michael Osterholm, an infectious-disease expert at the University of Minnesota, has told me.

    The recent declines, for example, have occurred even as millions of American children have again crowded into school buildings.

    Hospitalizations, too

    Whatever the reasons, the two-month cycle keeps happening. It is visible in the global numbers, as you can see in the chart below. Cases rose from late February to late April, then fell until late June, rose again until late August and have been falling since.

    oakImage-1633278338031-articleLarge.png

    The pattern has also been evident within countries, including India, Indonesia, Thailand, Britain, France and Spain. In each of them, the Delta variant led to a surge in cases lasting somewhere from one and a half to two and a half months.

    In the U.S., the Delta surge started in several Southern states in June and began receding in those states in August. In much of the rest of the U.S., it began in July, and cases have begun falling the past few weeks. Even pediatric cases are falling, despite the lack of vaccine authorization for children under 12, as Jennifer Nuzzo of Johns Hopkins University told The Washington Post. (You can see the overall trends for every state here.)

    The most encouraging news is that serious Covid illnesses are also declining. The number of Americans hospitalized with Covid has fallen about 25 percent since Sept. 1. Daily deaths — which typically change direction a few weeks after cases and hospitalizations — have fallen 10 percent since Sept. 20. It is the first sustained decline in deaths since the early summer.

    oakImage-1633278458184-articleLarge.png

    ‘The last major wave’?

    This is the part of the newsletter where I need to emphasize that these declines may not persist. Covid’s two-month cycle is not some kind of iron law of science. There have been plenty of exceptions.

    In Britain, for example, caseloads have seesawed over the past two months, rather than consistently fallen. In the U.S., the onset of cold weather and the increase in indoor activities — or some other unknown factor — could cause a rise in cases this fall. The course of the pandemic remains highly uncertain.

    But this uncertainty also means that the near future could prove to be moreencouraging than we expect. And there are some legitimate reasons for Covid optimism.

    The share of Americans 12 and over who have received at least one vaccine shot has reached 76 percent, and the growing number of vaccine mandates — along with the likely authorization of the Pfizer vaccine for children ages 5 to 11 — will increase the number of vaccinations this fall. Almost as important, something like one-half of Americans have probably had the Covid virus already, giving them some natural immunity.

    Eventually, immunity will become widespread enough that another wave as large and damaging as the Delta wave will not be possible. “Barring something unexpected,” Dr. Scott Gottlieb, a former F.D.A. commissioner and the author of “Uncontrolled Spread,” a new book on Covid, told me, “I’m of the opinion that this is the last major wave of infection.”

    Covid has not only been one of the worst pandemics in modern times. It has been an unnecessarily terrible pandemic. Of the more than 700,000 Americans who have died from it, nearly 200,000 probably could have been saved if they had chosen to take a vaccine. That is a national tragedy.

    Covid also isn’t going to disappear anytime soon. It will continue to circulate for years, many scientists believe. But the vaccines can transform Covid into a manageable disease, not so different from a flu or common cold. In the past few weeks, the country appears to have moved closer to that less grim future.

    Whatever this autumn brings, the worst of the pandemic is almost certainly behind us.

  • The saga of pandemic response [in the US] is reaching what seems to be its final possible iteration: some conservatives are now saying covid-19 is a good thing, New York Magazine’s Jonathan Chait writes.

    The coronavirus pandemic has offered an especially grisly illustration of the pathological nature of American conservatism. President Trump initially wobbled between trying to contain the pandemic and denying it before settling on the latter posture. It therefore became a matter of loyalty for conservatives to support Trump’s claims that COVID was just the flu, that it would disappear quickly, and that the hysteria was being whipped up by his enemies in a plot to destroy his beautiful economy.”

  • Covid: Why are UK cases so high?
    The UK has higher infections than most of its neighbours, as scientists fear a difficult winter.
    www.bbc.com


    What is Covid Plan B and what are the rules across the UK this winter?
    Health service figures are calling for stricter Covid restrictions in England to protect the NHS.
    www.bbc.com


    A friend said this morning how can there be a plan B when they never had a plan A....